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The Latest Breaking News from Isaac Guerendo

No guarantee breakout offensive star returns to 49ers in 2025

The 49ers have a tough choice at RB.

USA Today Sports Media Group

49ers rookie may have avoided major injury in loss to Cardinals

San Francisco provided an initial injury update on RB Isaac Guerendo following the 49ers' season finale vs. Arizona.

USA Today Sports Media Group

Cardinals 47, 49ers 24: Kyler Murray throws 4 TD passes in season finale blowout

The Cardinals finish the season 8-9 with a 47-24 win over the 49ers behind four TD passes from Kyler Murray.

USA Today Sports Media Group

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49ers RB Isaac Guerendo carted off with knee and ankle injuries

49ers RB Isaac Guerendo was carted off early vs. Arizona.

USA Today Sports Media Group

Another 49ers RB hurt!

The 49ers' rookie RB was carted off the field against the Cardinals and ruled out the rest of the game.

USA Today Sports Media Group

Prediction and betting odds for 49ers vs. Cardinals in Week 18

Analyzing Sunday's 49ers vs. Cardinals game with odds and lines, predictions and best bets.

USA Today Sports Media Group

Film room: Detroit Lions defense made plays despite some struggles and miscues

Film room: Detroit Lions defense made plays despite some struggles and miscues against the 49ers

USA Today Sports Media Group

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Is Isaac Guerendo playing this week? Injury updates for 49ers RB

49ers RB Isaac Guerendo was dealing with a hamstring injury. Here are the latest updates leading up to Week 17's game vs. the Lions.

USA Today Sports Media Group

Lions vs 49ers: Final injury report medical analysis

Lions vs 49ers: Final injury report medical analysis for Week 17

USA Today Sports Media Group

Lions vs 49ers: Initial injury report medical analysis and IR-list update

Lions vs 49ers: Initial injury report medical analysis and I.R. list update for Week 17

USA Today Sports Media Group

Good news for RB Isaac Guerendo in 49ers Week 17 injury update

Hey here’s some good news!

USA Today Sports Media Group

Rookie 4th-round pick has helped 49ers avert another disaster

It finally happened!

USA Today Sports Media Group

Fantasy Football: 5 waiver wire running backs to target in Week 17

Trey Benson is among the top running backs to target on the fantasy football waiver wire this week.

USA Today Sports Media Group

Kyle Shanahan optimistic about breakout RB’s return in Week 17 vs. Lions

Isaac Guerendo is on track to return in Week 17.

USA Today Sports Media Group

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USA Today Sports Media Group

49ers combat injuries with roster moves ahead of Week 16

The 49ers made a bunch of roster moves before Week 16.

USA Today Sports Media Group

Will Isaac Guerendo play this week? Injury updates for 49ers RB

49ers running back Isaac Guerendo is dealing with a hamstring injury. Here are the latest updates.

USA Today Sports Media Group

What to expect from ‘likely’ new 49ers starting RB

It'll be a 4th different starting RB for the 49ers on Sunday.

USA Today Sports Media Group

49ers injury report for Week 16 is full of bad news

All the latest updates and news on 49ers' injury report ahead of a Week 16 game vs. Dolphins.

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USA Today Sports Media Group

49ers superstar downgraded in updated Week 16 practice report

Nick Bosa was limited for Wednesday's practice. He was out for Thursday's session.

Sports Illustrated

49ers Will Be Without Another Running Back vs. Dolphins

Isaac Guerendo is the latest 49ers running back to suffer an injury.

USA Today Sports Media Group

New injury update for Isaac Guerendo isn’t promising for 49ers rookie

The San Francisco 49ers will have a fourth different starting RB against the Miami Dolphins.

USA Today Sports Media Group

49ers open Week 16 practice with 3 players missing, 5 limited

The San Francisco 49ers had a busy practice report to open Week 16 preparations for the Miami Dolphins.

USA Today Sports Media Group

More bad injury news for another 49ers RB leading up to game vs. Dolphins

Another RB injury...

Sports Illustrated

Start 'Em, Sit 'Em Running Backs for Fantasy Football Week 16

Start ‘Em, Sit 'Em advice for RBs in fantasy Week 15 led by James Conner and Najee Harris.

USA Today Sports Media Group

49ers inactives: Lots of good injury news vs. Rams

Thursday Night Football against the Rams will mark the return of two key pieces on the 49ers' defense.

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