Katie Prager died Thursday, five days after her husband Dalton. Both had cystic fibrosis and complications from lung transplants.
Prager, 26, was in hospice care at her home in Kentucky.
"We were given a great gift, we knew her time was short and she was able to do a few things that she wanted, and I am grateful for that," Katie Prager's mother Debbie Donovan wrote on the couple's Facebook page. "The days to follow will not be easy but I find comfort in knowing that my girl lived, she really lived."
Dalton Prager, 25, died Saturday at Barnes-Jewish Hospital in St. Louis, where he had been treated to be closer to family.
The couple longed to see each other again before they died, but neither were healthy enough to travel.
The Pragers were featured in a story in the Post-Dispatch last week about their fight to be together.
They were born with the genetic disorder that attacks the lungs and also affects the digestive system and multiple other organs. They met through a mutual friend, and were married five years ago.
Both received lung transplants but developed complications including lymphoma.
