There's a rumour over on the Nintendo.com forums, that information from the Wii weather channel affects in-game conditions in certain titles. For example, if users load up Madden while it's snowing outside - hey presto, it'll be snowing in the game (as long as they've registered their location correctly, I presume). This, of course, has been seen in flight sims for several years as well as a few mobile games, but might be a first on console. Or did Shenmue do it? I can't remember.
Nintendo fans are currently fantasising over which games this would work well with - Animal Crossing being the obvious recipient.