The 70-year-old progressive lawmaker is to meet her campaign staff to announce that she is suspending her bid for the party's presidential nomination, The New York Times, CNN and other US media outlets said.
Warren led some national polls last summer but she never managed to build a broad coalition to carry her through to success in the primaries, finishing behind fellow progressive Bernie Sanders and moderate Joe Biden in 14 states on Super Tuesday.
Warren's withdrawal makes the Democratic race effectively a two-man contest between Biden, the 77-year-old former vice president, and Sanders, the 78-year-old Vermont senator.
No intention to boost Biden or Sanders
Warren finished third in her home state of Massachusetts behind Biden and Sanders on Tuesday.
Her decision to drop out comes one day after that of billionaire former New York mayor Michael Bloomberg, who quit on Wednesday after a disappointing Super Tuesday performance and endorsed Biden.
According to the Times, Warren does not plan to make an endorsement when she announces that she is quitting the race.
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