Two men in their 20s have been arrested on suspicion of dealing drugs in St Paul's.
Officers searched a property in the Portland Square area on January 30.
They seized a large amount of cash and what are believed to be Class A drugs, which will be forensically tested.
Police say the men - both from London - appear to have been seen making drug exchanges in the area and going in and out of the property, which led to the house search.
A spokesperson for Avon and Somerset Constabulary said: “The men have been arrested on suspicion of drug dealing and possession of criminal property.
"They are both suspected to be involved in county lines drug dealing and have been released under investigation.”
"The Bristol East neighbourhood policing teams are increasingly noticing that these type of residences are being used by organised crime groups to run illegal practices, such as drug dealing and brothels for short periods, to try to evade attention by the authorities."
The force encouraged the local community to report unusual or suspicious behaviour.
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Anyone with information should call 101, quoting reference 5220024356.
Reports can also be made anonymously to Crimestoppers on 0800 555111 or report it on-line using this link quoting the above reference number.
They never ask your name or trace your call.
