Hugo Lloris' dislocated elbow means Paulo Gazzaniga is set for a run of games until at least January, with the returning Michel Vorm as back-up goalkeeper.
Mauricio Pochettino could use his sixth right-back of the season if Juan Foyth is deemed fit enough to start after two appearances for Argentina over the international break but Moussa Sissoko may continue in the role.
The manager may also freshen up the centre of defence after shipping 10 goals in two matches with Toby Alderweireld and Jan Vertonghen at centre-half; Davinson Sanchez is pushing for a place.
With Christian Eriksen doubtful with a dead leg picked-up on Denmark duty and Heung-min Son unlikely to start after playing in North Korea on Tuesday evening, Dele Alli and Lucas Moura seem likely choices in attack after not being selected for their countries.
Here's what we expect the Tottenham XI vs Watford to look like…
Tottenham 4-2-3-1: Gazzaniga; Sissoko, Sanchez, Alderweireld, Rose; Winks, Ndombele; Lucas, Alli, Lamela; Kane
Predict the results for gameweek 9 in the Premier League
