Thomas Frank admitted Manchester United have a key advantage over Tottenham ahead of their lunchtime meeting on Saturday.
The two sides will go head-to-head in north London for the first time since the Europa League final in May.
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Victory in Bilbao earned Spurs a place in this season's Champions League football, while United are not involved in any European competition.
Their calendar was further cleared when they fell at the first hurdle in the Carabao Cup against Grimsby.
Ruben Amorim's side have had a full week to prepare for their trip to Spurs, who were in action midweek against Copenhagen in the Champions League.
"No doubt it’s an advantage, no doubt," Frank said.
"I said from the beginning we want to be able to compete in both because of where we want to be, we need to be able to perform in Champions League, Europa League and still top perform in the league.
"There’s no two ways about it, that’s for the fans, the status, the money, everything, the ambitions, what we want to achieve.
"But to have a week to prepare for a game, to have the freshness, that means something."
Spurs and United both go into the match with five wins, two draws and three defeats from their opening ten matches of the Premier League season.
It is a very congested table. The sides sit two points off Manchester City in second but only the same amount clear of Aston Villa in 11th.
"I think in general the Premier League this season is the most competitive Premier League I’ve seen," Frank said.
"This is my fifth year here and there’s so little between the teams. If I see the other games, I heard [Arne] Slot talk about the [Liverpool vs] Villa game, small margins in that game as well, the momentum change in games - it’s very, very competitive."
