New South Wales coach Brad Fittler has made seven changes to his squad for next Sunday's must-win State of Origin II in Perth.
Matt Burton, Angus Crichton, Clint Gutherson, Jordan McLean, Victor Radley, Siosifa Talakai and Jake Trbojevic all come in to the 22-man squad.
Burton, McLean, Radley, Talakai, Joseph Suaalii and Nicho Hynes are in line for possible debuts.
Fittler will not confirm his 17 until Monday morning, immediately after which the squad will travel to Perth.
Reagan Campbell-Gillard, Tariq Sims, Jacob Saifiti, Tyson Frizzell, Kotoni Staggs and Jack Wighton have all been omitted
Raiders star Wighton was forced out of Game II due to COVID protocols, having been the Blues' stand-out in Game I.
Canterbury's Burton is in contention to play left centre in place of Staggs but there is no place for fellow Bulldog Josh Addo-Carr, who has scored five tries in the three games since being snubbed for Origin I.
Api Koroisau will likely come off the bench to assist Rabbitohs hooker Damien Cook, who was oddly quiet in the Game I defeat after being a non-playing squad member for Game I.
The Blues must win game two at Perth Stadium on June 26 in order to keep the series alive after losing game one in Sydney, 16-10.
Maroons coach Billy Slater is set to name his squad on Monday morning.
Blues squad: James Tedesco (captain), Matt Burton, Nathan Cleary, Damien Cook, Angus Crichton, Stephen Crichton, Clint Gutherson, Payne Haas, Nicho Hynes, Apisai Koroisau, Jarome Luai, Liam Martin, Jordan McLean , Cameron Murray, Junior Paulo, Victor Radley, Joseph Suaalii, Siosifa Talakai, Brian To'o, Jake Trbojevic, Daniel Tupou, Isaah Yeo.