A Hard Rock hotel collapsed in downtown New Orleans leaving one person dead and three people missing.
Shocking footage shows pedestrians scrambling for cover as the top floors of the building fell to the ground in a giant cloud of dust.
Another harrowing video shows cars frantically trying to escape falling debris as terrified tourists watch on.
The incident happened on Canal Street, a major thoroughfare through the centre of New Orleans, on Saturday morning.
First responders from the fire and police departments are at the scene with at least 18 injured people taken to hospital, reports nola.com.
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New Orleans Fire Department spokesperson Tim McConnell said the structure of the upper building remains very unstable.
At least one person is dead and several people are unaccounted for, according to Louisiana State Governor John Bel Edwards.
The city's emergency response authority urged locals to stay away from the area.
It tweeted: "This is an active scene. Please avoid the area & listen to public safety officials. "
Around 45 people were working on the site, according to reports.
One bystander said he saw workers "hanging on", with the crane "just sort of dangling there."
"It was a deep, rumbling sound, like an airplane maybe. It drew my head immediately", another eyewitness said.
"It looked like the concrete just slid from the top all the way down to the street.
He also recounted how one bystander narrowly escaped death.
"One guy -- I don't know how he was spared -- there was rubble all around him."
The 350-room Hard Rock Casino hotel was slated to open in the spring of 2020 and has been under construction for around a year.
