Despite teasing his return to bid a farewell to the United fans, Paul Pogba has been ruled out having failed to recover from a calf injury ahead of his contract expiring.
But the Red Devils has received boosts on multiple fronts before the trip to Selhurst Park.
Marcus Rashford and Jadon Sancho are back in training after bouts of illness but neither are named in the squad, along with Luke Shaw. The left-back is away for personal reasons after the birth of his second child.
Rangnick did also admit a “number” of players are suffering with knocks and, given the rebuild expected, many may have already their final game for the club.
One of those is Cristiano Ronaldo, who misses out with a hip problem.
A number of youngsters have joined first-team training this week and could stake their claim as Erik ten Hag watches on before officially taking charge of the team.
Hannibal Mejbri starts with Alejandro Garnacho, Charlie Savage and Shola Shoretire all on the bench.
Manchester United XI: De Gea; Dalot, Lindelof, Maguire, Alex Telles; McTominay, Fred; Elanga, Bruno Fernandes, Mejbri; Cavani.
Subs: Bailly, Jones, Mata, Varane, Heaton, Shoretire, Savage, Fernandez, Garnacho.