Newcastle United boss Steve Bruce made a host of changes as the Magpies looked to keep Ronaldo quiet at Old Trafford.
The global icon started the game to make his Man United bow as a packed crowd waited for hours before the kick off just to roar him off the bus.
But for under pressure Bruce he knew he had to shake things up after just one point from the opening three matches.
Bruce stuck with Freddie Woodman while Isaac Hayden returned but as part of a back five.
Javier Manquillo replaced Jacob Murphy while Miguel Almiron was cleared to play.
And it was Joelinton who replaced the injured Callum Wilson.
Bruce also named Joe White on the bench as players like Fabian Schar and Federico Fernandez were dropped.
There was no place for Dwight Gayle in the starting line-up.
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Today's teams
Newcastle United: Woodman, Manquillo, Hayden, Lascelles, Clark, Ritchie, Longstaff, Willock, Almiron, Saint-Maximin, Joelinton
Subs: Darlow, Schar, Fernandez, Krafth, Lewis, Hendrick, Murphy, White, Gayle
Manchester United: D e Gea, Wan Bissaka, Varane, Maguire, Shaw, Pogba Matic, Greenwood, Bruno Fernandes, Sancho, Ronaldo.
Subs: Lindelof, Bailly, Mata, Martial, Lingard, Fred, Dalot, Heaton van de Beek.
