Manchester United have named Victor Lindelof, Anthony Martial and Paul Pogba in their side to face Liverpool today.
Ole Gunnar Solskjaer has made three changes from the United side that beat Burnley 1-0 in midweek, with Lindelof, Scott McTominay and Fred coming in for Eric Bailly, Nemanja Matic and Edinson Cavani.
Those three players have to make do with a place on the bench, as does fellow summer signing Donny van de Beek.
Leaders United go into the game at Anfield knowing that a draw will retain their three-point advantage over third-placed Liverpool, though a victory will stretch the gap to six points.
Liverpool have picked a centre-back combination of Fabinho and Jordan Henderson, with Thiago Alcantara, Gini Wijnaldum and Xherdan Shaqiri in midfield.
Before the game, Solskjaer prepared his players for a huge challenge in going to Anfield and trying to win.
"The boys have to be confident going into the games when you get results and performances like we’ve had," he told United's official website. "It’s human nature. Confidence is not just something you can give them, they work to get that confidence.
"Then going away to Anfield, playing against the champions who haven’t lost there for three-and-a-half years, that’s a different challenge. That’s not one that you just turn up to and win because we’re confident.
"There is much more than that which has to go into the game and preparation. It’s about the mindset and how you prepare your head for every single little moment because we know in these games that small moments can decide them. We saw that in the Carabao Cup [against Man City] when we conceded from set plays and last time we lost to Liverpool they had a corner and scored and we had a corner in the last minute and they counter-attacked and scored.
"So there are fine margins and small differences… maybe a decision that’s wrong or right that can change the whole course of a game or a season.”
United XI: De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; Fred, McTominay; Pogba, Fernandes, Rashford; Martial.
Subs: Henderson, Tuanzebe, Bailly Telles, Matic, Van de Beek, Mata, Greenwood, Cavani.
Liverpool XI: Alisson; Alexnader-Arnold, Fabinho, Henderson, Robertson; Thiago, Wijnaldum, Shaqiri; Salah, Firmino, Mane.
Subs: Kelleher, Milner, Oxlade-Chamberlain, Jones, N. Williams, R.Williams, Minamino, Origi, Phillips.
