There's no such thing as a sure thing in the NFL. About the only thing you can predict is that on almost every other play a receiver will call for a pass-interference flag. As for predicting games, who would've thought that the Rams, who were embarrassed six days earlier by the 49ers, could beat the Seahawks?
Underdogs went 8-8 against the spread (ATS) in Week 2, making them 19-13. There are eight 2-0 teams, eight 0-2 teams and the remaining 16 are 1-1. While those winless teams' motivation factor could make them wise bets this week, it's all about looking at each matchup and not trying to overreact to the week before.