Some things never change in the NFL. From head-scratching replays _ let's hope the league finally has figured out what a catch is this season _ to coaches punting when they should go for it on fourth-and-short, expect more of the same. When it comes to Week 1, though, you never know what's in store. It's right up there with Week 17 as the most difficult weeks to break down.
Be on the lookout for home underdogs, especially early in the season. This week, five teams _ the Redskins, Lions, Bears, Browns and 49ers _ are getting points at home, so there could be some value there.
There's one fewer game on the schedule, as the Bucs-Dolphins opener in Miami was postponed because of Hurricane Irma.
Of the remaining games, these are my most confident picks against the spread (ATS): 49ers, Titans, Chargers, Saints, Giants, Rams and Bengals. Ones that could be tricky and you may want to stay away from: Redskins-Eagles, Cardinals-Lions, Steelers-Browns, Bills-Jets and Seahawks-Packers.