Ulster prop Eric O’Sullivan will be the 12th debutant capped by Andy Farrell when he comes off the bench against Scotland on Saturday.
Ireland boss Farrell has made five personnel changes to his side for the Aviva Stadium clash, which is effectively the third and fourth place play-off in the Autumn Nations Cup, plus one positional change.
Johnny Sexton, Robbie Henshaw and Bundee Aki return to the backline.
In the pack, Rob Herring is given the nod ahead of Ronan Kelleher for the hooker role, so the front row and back row remain the same as for last week’s laboured win over Georgia.
But the back row sees another change-up as Caelan Doris returns at no 8, CJ Stander moves to the blindside again and Peter O’Mahony is back in the openside role.
With Billy Burns ruled out, Ross Byrne will be Sexton’s back-up.
Meanwhile, Scots boss Gregor Townsend has made six changes to his side, including handing a debut to Edinburgh out-half Jaco van de Walt, for Saturday’s clash.
“We have been impressed with Jaco over the time he has trained with us and we’re excited to see him take the next step into international Test match rugby,” said Townsend.
“It will be a tough challenge over in Ireland, given the quality of our opposition and how they will be looking to end 2020 on a positive note.”
Skipper Stuart Hogg will win his 80th cap and, at inside centre, Duncan Taylor makes his first Scotland start since the defeat of Russia at last year’s Rugby World Cup.
Townsend said: “We’ve been together for the past two months and from a coaching perspective it has been a real joy seeing the group come together and work so hard to improve both individually and collectively.
“We are looking forward to facing Ireland in what will be an opportunity to continue our progress away from home once again.
“Being able to bring back Rory Sutherland after his recent injury is a real boost, and it’s great to involve Blair and Huw for the first time this season.
“If they get on the field, 39 players will have had opportunities to play over the past five games, which underlines the current player depth throughout Scottish rugby and shows the competition there is for places now in this Scotland team.”
Ireland: Stockdale, Keenan, Henshaw, Aki, Earls, Sexton, Murray; Healy, Herring, Porter, Henderson, Ryan, Stander, O’Mahony, Doris.
Replacements: Kelleher, O’Sullivan, Ryan, Roux, van der Flier, Gibson-Park, Byrne, Farrell.
Scotland: Hogg, Graham, Harris, Taylor, van der Merwe, van der Walt, Price; Sutherland, Brown, Fagerson, Cummings, Gray, Thomson, Ritchie, Fagerson.
Replacements: McInally, Kebble, Neil, Skinner, Cowan, Hidalgo-Clyne, Jones, Maitland
