Here is a full look at the Pittsburgh Steelers 2022 NFL regular-season schedule. The season gets off to a big start with three straight games against teams that made the playoffs last season, two of which are AFC North division rivals.
| Week | Date | Opponent | Time (CT) | ||
| 1 | Sept. 11 | at | Cincinnati Bengals | 1:00 p.m. | Tickets |
| 2 | Sept. 18 | vs. | New England Patriots | 1:00 p.m. | Tickets |
| 3 | Sept. 22 | at | Cleveland Browns | 8:15 p.m. | Tickets |
| 4 | Oct. 2 | vs. | New York Jets | 1:00 p.m. | Tickets |
| 5 | Oct. 9 | at | Buffalo Bills | 1:00 p.m. | Tickets |
| 6 | Oct. 16 | vs. | Tampa Bay Buccaneers | 1:00 p.m. | Tickets |
| 7 | Oct. 23 | at | Miami Dolphins | 8:20 p.m. | Tickets |
| 8 | Oct. 30 | at | Philadelphia Eagles | 1:00 p.m. | Tickets |
| 9 | Nov. 6 | Bye Week | Tickets | ||
| 10 | Nov. 13 | vs. | New Orleans Saints | 1:00 p.m. | Tickets |
| 11 | Nov. 20 | vs. | Cincinnati Bengals | 8:20 p.m. | Tickets |
| 12 | Nov. 28 | at | Indianapolis Colts | 8:15 p.m. | Tickets |
| 13 | Dec. 4 | at | Atlanta Falcons | 1:00 p.m. | Tickets |
| 14 | Dec. 11 | vs. | Baltimore Ravens | 1:00 p.m. | Tickets |
| 15 | Dec. 18 | at | Carolina Panthers | 1:00 p.m. | Tickets |
| 16 | Dec. 24 | vs. | Las Vegas Raiders | 8:16 p.m. | Tickets |
| 17 | Jan. 1 | at | Baltimore Ravens | 1:00 p.m. | Tickets |
| 18 | TBD | vs. | Cleveland Browns | TBD | Tickets |
