Laetitia Beck birdied five of her first nine holes and added three on the home stretch to set the pace at the first round of the LPGA in Galloway.
Beck's bogey-free, eight-under 63 earned her a one-shot lead over Denmark's Nicole Broch Estrup.
Briana Chacon, Germany's Polly Mack and Thailand's Arpichaya Yubol were tied for third at six-under 65 at the Bay Course at Seaview Hotel & Golf Club.
Beck, the first Israeli player in LPGA history who last year picked up her first win on the developmental Epson Tour, took only 25 putts on a strong day on the greens.
She has been around for 12 years and yet to win on the LPGA or the Ladies European Tour. But she isn't about to let a career-low score get her thinking too far ahead.