The Taliban has claimed responsibility for those deaths. Yet, given the media's fascination with all that happens in Iraq and its focus on the US presidential elections, this event received far too little attention, as does the steady collapse of law and order in Afghanistan itself.
These assassinations, and the subsequent withdrawal of MSF from Afghanistan, could have a far-reaching effect.
To understand why, it is necessary to understand MSF's importance in world affairs. This extraordinary organization was founded by a group of French doctors in 1971 to provide emergency medical assistance during wartime and in crisis areas.
Currently, it has around 2,500 volunteers (including doctors, nurses and technical support), joined by roughly 15,000 local staff across the globe. MSF, active in 80 countries, goes into places where angels fear to tread.
Being one of the first non-governmental organisations to go into troubled zones - such as western Sudan - MSF draws international attention to burgeoning crises. It will also go into countries after the fighting is over to pick up the pieces, so to speak.
MSF is usually welcomed by all sides in a dispute or a famine because its intentions are so transparent - to bring medical services, food supplies and sanitation. Its charter proudly states that its volunteers "are aware of the risk and dangers of the mission they undertake, and have no right to compensation for themselves or their beneficiaries other than what Médecins sans Frontières is able to afford them."
While MSF strives to avoid taking sides, it is not bound to political neutrality in word and deed, like the international committee of the Red Cross. For example, in 1999 - the same year that MSF was awarded the Nobel Peace Prize - the group's chairman openly appealed to the then Russian president, Boris Yeltsin, to stop the bombing of civilians in Chechnya.
Before announcing its decision - after much agonising - to withdraw its 80 foreign volunteers from Afghanistan and dismiss its 1,400 local staff, MSF had worked in the country for 24 years. The group had become famous decades earlier by bringing medicine to stricken Afghan communities by packhorse and mules.
It is hard to read about this withdrawal without shedding a tear. And, as I write this piece, the word comes in that MSF is scaling down its work in neighboring Pakistan because of worries over imitation attacks.
So two poor and populous countries in great need of the MSF's unselfish work are now made to suffer from calculated extremist attacks. And other relief organizations are also considering pulling out of Afghanistan. Overall, 30 relief workers were killed in the country during the first six months of this year. Why can't this be headline news?
That, alas, is not the worst of it. The MSF deaths, and the organisation's decision to withdraw from Afghanistan, point to two big questions about international peace and security in the 21st century.
The first is whether any international relief group (devoted to human rights, women's issues, the environment, childcare) that has its headquarters in New York, Paris, Geneva or Vienna can avoid the suspicion that it is just another form of western intrusion in a troubled land - and thus be denounced and attacked by malcontents.
Are not German religious and relief workers in distraught Kosovo part of a NATO plot? Is not the news that Tony Blair has asked the British chiefs of staff to prepare plans to send a military contingent to Darfur to stop the dreadful genocide just another demonstration of the west's continuing imperialistic ambitions?
To many of us, these seem totally absurd suspicions. Yet, when one learns of MSF's complaints that the US military had badly mixed its role in Afghanistan with those of the civilian aid groups - by distributing relief to communities that would offer intelligence and also by sometimes wearing civilian clothes - one cannot be completely surprised at the local response, even if it was carried out by extremists.
This leads to the most disturbing question of all: can the UN, the great and small powers that are central members of it, and the agencies that report to and support it, maintain the current assumption that a distinction can be made between its "hard" work (peace enforcement, chapter seven operations, eliminating rogue states) and its "soft" work (rebuilding economies and helping the distressed, wounded, displaced and other victims of conflict and disaster)?
In most past peacekeeping operations, that was a reasonable assumption. Local antagonists would be very willing, as in Mogadishu in 1993, to damage the UN's (or the delegated US's) armed forces. But neutral, philanthropic and church-based organisations on the ground were rarely assaulted. That is no longer the case.
Why? The answer is perfectly plain. For some years now, scholars in what is called the "security community" (ie those who think about war and peace) have been discussing the problem of asymmetrical warfare.
The logic chain goes like this: The US is in such a dominant position in terms of traditional military power (right now, it may well be spending one-half of the world's total defence expenditure) that its various foes are not going to attack it in a battle of Midway manner, big fleet against big fleet.
No, they will attack the US in a sneaky, underhand way, as in 9/11. They will attack the nation's weak points, not its strengths. This is why there are large cement blocks outside the New York Stock Exchange and checks on trucks going up and down the coasts, and why people take off their shoes at airports.
This is why the US is demanding that its new embassy in Berlin should be in an area totally open on all sides (never mind the historic district that will be obliterated).
But abroad, generally, and in the Middle East, in particular, where both the present US administration and its Democratic contenders maintain that the country has vital interests, the asymmetrical attacks are coming to us in a much subtler way, as the deaths of the five MSF volunteers prove.
Our enemies, while still doing daily battle for Falluja, keep conjuring up new ways to hurt us. Why not also blow up a gas line? Why not kill Turkish truck drivers? Why not destroy men lining up outside an Iraqi police station in the hope of recruitment?
Above all, why not hit the "soft" parts of the international system? Why not bomb the UN headquarters in Baghdad and kill lots of outstanding people, including that remarkable ambassador for peace, Sergio Vieira de Mello? And, after you have committed such a terrible crime, why not, indeed, kill an MSF team?
What could the next boundary of atrocity be? How far can this madness go? A nursing home in Chicago?
There are no answers to such questions that, for me, carry any surety. And I am left, sadly, with John Donne's immortal poem about troubled times, the title of which is the headline of this humble piece. "No man is an island, entire of itself," Donne wrote. All of us, not just in Asia and the Middle East, are going to feel the pressures described above.
Not even the US can escape Donne's words these days. Therefore, do not ask for whom the bell tolls. It tolls for thee.
© Tribune Media Services International, 2004
· Paul Kennedy is Professor of History and Director of International Security Studies at Yale University, and the author/editor of 16 books, including The Rise and Fall of Great Powers