Manuel Pellegrini has made two changes from the team that drew with Leicester City for Saturday lunchtime's London derby against Spurs.
In come Ryan Fredericks at right back and Issa Diop makes his first start since April 8 having been on the bench for the last three games. Out go Pablo Zabaleta and Angelo Ogbonna.
Fredericks inclusion is likely to combat the pace Son Heung-min on the left of Spurs' front three, while Diop's inclusion reunited him with Fabian Balbuena, a partnership that impressed hugely before the turn of the year and the Paraguayan's knee injury.
Javier Hernandez is also back in the squad but only makes the bench having missed the draw against the Foxes with an ear infection.
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The rest of the side is unchanged from last Saturday as Mark Noble, Declan Rice and Robert Snodgrass make up the midfield three. The front three too remains the same with Michail Antonio, Felipe Anderson and Marko Arnautovic starting in the final third.
Manuel Lanzini and Aaron Cresswell have both not made the squad for the game after recovering from injury but Javier Hernandez is back in the 18 and has made the bench.
West Ham are aiming to be the first team to win at Spurs' new stadium since Mauricio Pochettino's side moved to their £1bn arena in north London after nearly two years at Wembley. Spurs have yet to even concede a goal at their new home, let alone lose.
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West Ham: Fabianski; Fredericks, Diop, Balbuena, Masuaku; Rice, Noble, Snodgrass; Antonio, Anderson, Arnautovic.
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