As the Indianapolis Colts prepare to host the Seattle Seahawks in the regular-season opener on Sunday, the game will come down to a handful of matchups likely to determine the outcome.

The Colts may have the advantage in some matchups while the Seahawks will be favored in others. Given that this game is expected to be a tightly contested bout, these matchups will hold a vital role in determining the winner to open the 2021 season.

Here are the key matchups to watch between the Colts and Seahawks in Week 1: