TORONTO _ A couple of hanging pitches in the strike zone cost Masahiro Tanaka dearly.
Tanaka was burned twice by the long ball in Tuesday night's fifth inning, as the Blue Jays held on for a 4-3 victory before 20,671 fans at Rogers Centre.
After Sunday's defensive misadventures and postgame disappearing act, Clint Frazier belted a two-run homer off starter Clayton Richard for a 2-0 Yankees lead in the fourth.
But Tanaka gave up four runs in the fifth, starting with a leadoff homer by Randal Grichuk.
An overturned call on a Cavan Biggio stolen base attempt set up a go-ahead, two-run homer by Freddy Galvis, with one out.
Eric Sogard's two-out double was followed by an RBI single from rookie Vladmir Guerrero Jr.
Aaron Hicks' eighth-inning solo homer cut it to 4-3, but the Yankees (38-21) couldn't mount a further rally against the Blue Jays (22-38).
Tanaka (3-5) has just one victory in his last eight starts, and the Yankees have now lost two straight games for the first time since dropping a two-game set at Arizona, April 30-May 1.
