Five men and a 63-year-old woman were arrested after police raided ten homes across the country.
Drugs, ammunition and designer gear were seized during the raids across Merseyside, Greater Manchester, North Wales, and Durham.
Police recovered approximately 2kg of suspected amphetamine from three of the addresses along with ammunition and a large quantity of designer clothing worth in excess of £30,000, North Wales Live reports.
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Five men - aged between 28 and 50 - have been arrested on suspicion of conspiracy to supply drugs and one woman - aged 63 - has been arrested on suspicion of conspiracy to supply drugs and possession of ammunition.
All six individuals remained in custody for questioning on Wednesday.
On Wednesday Detective Inspector Justin Bryant said: "This has been a long-running investigation which our dedicated officers have been investigating for over six months alongside our partners from Merseyside Police, North Wales Police, Cheshire Police, and Durham Constabulary.
"Today we have been able to seize a significant amount of drugs and stop them from ever being able to reach our streets as well as disrupting an organised crime group in their criminal activity.
"Information from the public is invaluable in aiding us to prevent organised crime from hurting our communities.
"We would always encourage people to report anything suspicious to police - or alternatively, you can report information anonymously by contacting Crimestoppers on 0800 555 111."
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