The two giant killers of the fourth-round ties meet in a south London derby at Kingsmeadow on Saturday afternoon.
Both sides beat Premier League opposition in the last round, with the hosts knocking out West Ham 4-2 to reach the fifth round, while Milwall came from behind twice to record a 3-2 win over Everton.
However, both sides’ league form has suffered since, with Wimbledon’s victory over Walsall the only win for either team since their historic cup triumphs.
However, despite that victory the hosts sit bottom of League One and seven points from safety with just 14 matches remaining of the season.
Millwall, who saw off Hull before their defeat of Everton, are just three points above the relegation zone in the Championship meanwhile, although they have a game in hand on their rivals.
What time does it start?
Wimbledon vs Millwall kicks off at 3pm (GMT).
Where can I watch it?
The match will not be shown live on TV or online in the UK.
Independent Sport will keep you up to date with all the goals as they fly in via our live blog.
Highlights will be shown at 10:30pm on BBC One.
Predicted line-ups
Wimbledon: Ramsdale; Thomas, Nightingale, McDonald; Oshilaja, McLoughlin, Hartigan, Wordsworth, Seddon; Folivi, Pigott
Millwall: Archer; Romeo, Hutchinson, Cooper, M. Wallace; J. Wallace, Leonard, Williams, Ferguson; O’Brien; Gregory
Form guide…
Wimbledon: LLWLLW
Millwall: LDWDLD
Head-to-head…
Wimbledon 0 Millwall 1 (Cahill), First Divison, March 2004
Millwall 2 (Harris pen, Whelan) Wimbledon 0, First Division, September 2003
Wimbledon 2 (Shipperley, Agyemang) Millwall 0, First Division, March 2003
Millwall 1 (Nethercott) Wimbledon 1 (Nethercott og), October 2002, First Division, October 2002
Millwall 0 Wimbledon 1 (Cooper), First Division, February 2002
Odds…
Wimbledon to win: 3/1
Millwall to win: Evens
Draw: 12/5
Prediction… Millwall on penalties
