The weekly coronavirus testing that has been occurring across the Premier League throughout the season has now been accelerated to twice a week after the recent rise in cases across the country.
The most recent testing saw 40 positive results returned from 2,295 tests, with the likes of West Ham's Ryan Fredericks now in self-isolation for a ten-day period.
Non-League clubs have not been provided with the same rigorous testing programme as the Premier League, with players only being tested if they show symptoms.
West Ham's opponent in the FA Cup third-round, National League club Stockport County, had a number of positive results in November and have had their most recent league game against Eastleigh postponed due to cases in the Eastleigh camp.
FA protocols are in place to provide tests for all 64 teams left in the cup, these will take place 72 hours before their third-round ties, with the FA footing the bill. This should ensure that all involved on Monday evening are free from the virus and the match can take place safely.
If there are a number of cases in either camp the match could be postponed or even forfeited by the affected club.
A postponement would cause the FA a huge headache due to limited space in the calendar to rearrange the tie before the fourth-round takes place on the weekend of 23 January.
On Tuesday Sky Sports reported that no club will be forced to automatically forfeit the tie should they be unable to field a team due to coronavirus, with the FA to assess each case on an individual basis.
If a club is able to field 14 fit players then the fixture will take place as planned, with any club who feel that they cannot play, able to apply to the FA for a review of their circumstances.
This review would then decide whether the game can take place as scheduled, be postponed, or forfeited by the team that is unable to fulfil the tie.
Both Stockport County and West Ham will be tested on Friday ahead of the 8pm tie on Monday 11 January.