Boris Johnson moved quickly to replace former Health Secretary Matt Hancock by appointing Midlands MP Sajid Javid to take his place.
As the new Health Secretary Mr Javid becomes responsible for overseeing the Government's response to Covid-19, and ensuring the under-pressure NHS is able to cope with the massive backlog of people with other illnesses who need care.
It's not his first time in the Government. Mr Javid has previously been Culture Secretary, Home Secretary and Business Secretary. And he's been Chancellor in Boris Johnson's government - but resigned after a row with the Prime Minister over who he should appoint as his special adviser.
Read more: Hancock resignation statement
Today's announcement suggests that whatever bad blood existed between Mr Javid and Mr Johnson is in the past.
Mr Javid also stood for the party leadership in 2019, and was defeated by Mr Johnson.
He has previously warned that some people in the Conservative Party may be hostile to Muslims, and has urged the party to take the problem seriously.
In the formal announcement, Downing Street issued a statement saying: "The Queen has been pleased to approve the appointment of the Rt Hon Sajid Javid MP as Secretary of State for Health and Social Care."
Mr Javid is the son of a bus driver, whose father arrived in England from Pakistan in the 1960s with just a pound in his pocket.
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He's known by some friends at Westminster as the Saj. He made it to the final four in the race to become the next Tory leader, but dropped out and subsequently endorsed Mr Johnson.
He became MP for Bromsgrove, near Birmingham, in 2010.
As Home Secretary, Mr Javid said he experienced racism at an early age and "could have had a life of crime" after growing up on "Britain's most dangerous street".
Mr Javid, 51, is married to Laura, and has four children and a dog.
