One of these counties will be relegated from Division One of the Allianz Football League today unless winless and already relegated Meath can beat Monaghan in Clones.
Mayo returned to action with an emphatic win over their Connacht rivals Galway last weekend, while the Red Hands suffered defeat against Donegal, who they meet again in the Ulster Championship in just seven days time.
A draw would be enough for Tyrone to maintain their Division One status as they are one point ahead of Mayo in the league table.
Here's everything you need to know about the game:
Where does the match take place?
Elverys MacHale Park in Castlebar will host the match.
When does it start?
Throw-in is scheduled for 2pm.
What channel is showing the game?
The clash will be shown live on the TG4 player, with deferred coverage being televised on TG4 from 5.30pm.
You can also follow all the action with The Irish Mirror's live blog here.
Betting odds
Mayo win: 2/5
Tyrone win: 11/4
Draw: 15/2
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