It was the nightmare draw for Manchester United - Barcelona were arguably the team everyone wanted to avoid but if Ole Gunnar Solskjaer's season is to end with a trophy then the Reds will need to beat the Catalan giants.
After two spectacular results against PSG - who were on of the favourites for the competition - United fans will feel hopeful about the tie, but it will still be extremely difficult.
These two teams haven't met in this competition since the final in 2011, when Wayne Rooney scored United's only goal in the game in which Pep's Barca side comfortably won 3-1 thanks to goals from Messi, Pedro and David Villa.
Which TV channel is Manchester United vs Barcelona on?
Manchester United vs Barcelona will be LIVE on BT Sport 1 and BT Sport 4K UHD from 7pm on Wednesday April 10.
Kick-off from Old Trafford is at 8pm.
You will be able to follow all the action on our live blog as always.
Team news for Manchester United vs Barcelona
Manchester United manager Ole Gunnar Solksjaer spoke to the media today ahead of the Champions League quarter-final first leg with Barcelona tomorrow.
Solskjaer revealed his side will be without Ander Herrera for their Champions League quarter-final first leg with Barcelona.
Odds for Manchester United vs Barcelona (Sky Bet)
Manchester United - 13/5
Draw - 13/5
Barcelona - 1/1
Marcus Rashford to score and Man Utd to win in 90 minutes - 13/2
Man Utd to qualify - 3/1
Draw 2-2 - 12/1
Barcelona to miss a penalty - 18/1
