Manchester City will be looking to to correct the wrong of the first leg and comeback to beat Tottenham to advance to the Champions League semi-finals.
City find themselves a goal down after an uncharacteristically negative performance in the first leg at the Tottenham Hotspur Stadium.
Blues boss Pep Guardiola came in for some heavy criticism after he deployed defensive tactics and left stars such as Kevin De Bruyne and Leroy Sane on the bench, only bringing the pair on in the 89th minute when they could have little impact on the game.
They both started in the weekend's victory against Crystal Palace and both proved that they have to start in the second leg, with De Bruyne especially impressing as he wracked up his first two assists of the season.
History is not on City's side going in to the game. According to Opta, of the 32 previous occasions of a side losing the first leg of a two-legged Champions League tie 1-0 away from home, 10 went on to progress. Only 31%.
So it's going to take a big game for City to advance and keep the dreams of an unprecedented quadruple alive, but they are more than capable.
What TV channel is Man City vs Tottenham on?
Man City vs Tottenham will be televised on BT Sport 2 from 7pm on Wednesday, April 17.
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Kick-off from the Etihad Stadium is 8pm.
As always, you'll be able to follow all that happens right here on our live blog.
Highlights of the game will be available on BT Sport's YouTube channel after the match.
Team news for Man City vs Tottenham
Man City have been boosted by the return of Fernandinho to training and Raheem Sterling and Sergio Aguero being declared fit for the clash.
Fernandinho has been training 'with low intensity' after missing the victory against Crystal Palace on Sunday and there's another session later on Tuesday, which will determine how fit he is.
On Aguero's fitness Guardiola said: "Sergio Aguero needs competition, and needs a little time to get to his best condition. Tomorrow is not about physical condition. We want to get to semi-final, that is the challenge."
Aleks Zinchenko will likely miss out as Guardiola doesn't expect him to train.
Odds for Man City vs Tottenham (SkyBet)
Man City - 3/10
Draw - 9/2
Tottenham - 8/1
Bernardo to score first and City to win 3-1 - 66/1
Man City to win 2-1 - 8/1
Raheem Sterling to score first - 4/1
