Health Secretary Matt Hancock has today warned there will be tougher action needed to tackle the spread of coronavirus.
Mr Hancock is expected to impose strict new measures in a speech in the Commons today, following a sharp rise in cases and hospital admissions across the country.
This morning, Mr Hancock said the country was facing a "significant challenge", as many brace themselves to be moved up a tier.
He said: "We are facing a very significant challenge in the NHS right now.
"There has been a significant rise in the number of cases - the highest number of cases recorded yesterday, 53,000 cases.
"We are going to have to take further action. I'm going to set that out the House of Commons later today."
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We'll be bringing you live updates as the tier announcement is made in our blog.
Mr Hancock is expected to make his statement at 3pm today.
Prime Minister Boris Johnson chaired a meeting of the Government's Covid-19 Operations committee on Tuesday evening, when changes to the tier system were discussed.
With case rates rising in all regions of England, as well as the number of Covid-19 patients in hospitals, any review is likely to involve areas moving up a tier rather than down.
Areas that may be moved from Tier 3 to Tier 4 due to increasing case rates include parts of the East Midlands, such as Northamptonshire and Leicestershire, as well as all areas of the West Midlands metropolitan county.
Hartlepool in north-east England, along with a handful of areas in Lancashire - Blackburn with Darwen, Burnley, Pendle and Ribble Valley - could also be upgraded from Tier 3 to 4.
The Times also reported that ministers are also considering imposing the country's toughest measures on parts of the south west and Cumbria.