Barcelona and Borussia Dortmund are among the teams set to discover their Europa League play-off round opponents this afternoon.
Both sides have dropped into the competition from the Champions League and are joint-favourites to lift the trophy.
Rangers, Napoli and Lazio are among the sides who finished runners-up in their Europa League groups.
Here's what you need to know about the draw:
Where and when is it?
The draw takes place at UEFA headquarters in Nyon, Switzerland, on Monday 13 December.
What time does it start at?
It is scheduled to start at 12pm.
What channel is it on?
BT Sport 1 will show the draw live.
How does it work?
The eight teams who finished second in their Europa League group will be seeded and drawn against the eight sides who finished third in their Champions League groups.
No team can play a club from their group or any team from their own country.
The clubs who finished second in their Europa League groups will play the first leg of their last-16 tie away from home.
What teams are in the hat?
Europa League runners-up
Rangers
Real Betis
Real Sociedad
Napoli
Olympiakos
Dinamo Zagreb
Braga
Lazio
Champions League third-placed teams
Borussia Dortmund
Sheriff
Zenit
RB Leipzig
FC Porto
Barcelona
Atalanta
Sevilla
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