Tottenham welcome German Bundesliga high-flyers RB Leipzig to London tonight for the first leg of the last 16 tie between the sides.
Spurs were dealt a major blow to their chances with the news that Son Heung-Min suffered a broken arm in the 3-2 win over Aston Villa on Sunday.
With Harry Kane also out until April, Jose Mourinho has lost his two key men up front.
Leipzig, meanwhile, boast impressive attacking options such as highly-rated Timo Werner, sit second in the Bundesliga table, and topped Group G to make the Champions League last 16.
Here's everything you need to know ahead of the game.
What time is kick-off?
The action gets underway at 8pm tonight.
Where is it on?
The Tottenham Hotspur Stadium hosts the first leg.
Which Irish TV channel is showing the game?
Virgin Media Sport is showing the game - with build-up getting underway at 7pm.
Betting Odds
Tottenham 6/4
Draw 12/5
RB Leipzig 17/10
Quotes Corner
The situation couldn't be worse in terms of options," Mourinho said. "I think that's a very, very, very obvious situation. There is nothing that you can do.
"You are going to play with the players we have available. The players are going to give absolutely everything which is what they are doing. In some periods I was worried about not having attacking options on the bench.
"Now I don't have attacking options on the pitch.
"So again, analogies apart, are we going to give up or are we going to fight the way we can? We are going to fight the way we can."
