Leinster and Lyon have never met before in European competition, but last year's beaten finalists will travel to France confident of picking up yet another win this season.
They have yet to taste PRO14 defeat this year, and comfortably put Benetton to the sword in their European opener at the RDS.
Leo Cullen's men will be favourites to pick up yet another consecutive win despite being on the road, Lyon lost their first European game of the year 25-14 to Northampton.
Here's all you need to know about the game:
When is it on?
The match is set for kick off at 4.15 pm local time, 3.15 PM GMT on Saturday, 23rd November.
Where is it on?
The Matmut Stadium de Gerland in Lyon will host the game
What channel is it on?
The match will be shown live on BT Sport 3, with coverage beginning at 2:45 pm.
You will also be able to follow the match on the Irish Mirror Sport's live blog.
Teams
The teams will appear here when they're announced.
Betting Odds
Lyon 21/10
Draw 19/1
Leinster 2/5
If you haven't already, be sure to like our Irish Mirror Sport and Irish Mirror GAA pages on Facebook and follow us on Twitter.
