Pep Guardiola will be hoping his Man City side bounce back from their loss to newly-promoted Norwich last week, as they prepare for the visit of Watford.
City’s defensive crisis has worsened since their defeat at Carrow Road, with John Stones being ruled out for five weeks, alongside Aymeric Laporte who will be out until next year.
Fernandinho looks set to partner Nicolas Otamendi at the back, after the Brazilian midfielder took up the role for City's Champions League opener in midweek.
Watford will fancy their chances against a makeshift City defence, after an outstanding second-half comeback against Arsenal last weekend.
Quique Sanchez Flores will hope his side can build on their improved display following his re-appointment and start climbing the table, after picking up just two points since the start of the season.
Here is all you need to know ahead of the clash...
When is the match?
The match is on Saturday September 21, with kick-off scheduled for 3pm (GMT).
Where is the match taking place?
The match is taking place at Man City’s home ground, the Etihad Stadium.
What TV channel is the match on?
The match will not be shown live on TV in the UK due to broadcasting rights.
Can you stream the match live?
The match will not be streamed live in the UK due to broadcasting rights.
Betting odds from Thepools.com
Manchester City 1/8
Draw 17/2
Watford 20/1
