Wetherspoon will make up to 130 senior managers and staff redundant.
The company said the redundancies were as a result of a downturn in the pub trade since coronavirus.
Wetherspoon has written to all 417 employees at head office to warn them that the redundancies will take place.
Wetherspoon chief executive John Hutson said: "The decision is mainly a result of a downturn in trade in the pub and restaurant industry generally , a reduction in the company’s rate of expansion and a reduction in the number of pubs operated from 955 in 2015 to 873 today.
“We should emphasise that no firm decisions have been made at this stage.
“All head office employees will be affected by the process, with the exception of those working directly in Northern Ireland and the Republic of Ireland."
