Mark Noble makes only his fifth Premier League start of the season against Wolves as he comes into the West Ham side for the injured Declan Rice at Molineux.
Rice has been ruled out for at least a month with a knee injury he sustained on international duty with England.
The midfielder has played every minute in the Premier League so far this season but is sidelined for the start of the run-in as West Ham bid to seal a place in Europe.
West Ham captain Noble replaces Rice alongside Tomas Soucek in central midfield.Noble started at Old Trafford against Manchester United last month but before that the 33-year-old had not started in the Premier League since December.
Elsewhere, Arthur Masuaku is back from injury and goes straight into the starting XI as David Moyes returns to a 5-3-2 system.
Masuaku has not featured since undergoing knee surgery in December.
West Ham confirmed line-up: Fabianski, Coufal, Diop, Dawson, Cresswell, Masuaku, Soucek, Noble, Fornals, Lingard, Antonio.
Subs: Martin, Trott, Fredericks, Johnson, Balbuena, Alves, Bowen, Benrahma, Odubeko.
Wolves confirmed line-up: Patricio, Dendoncker, Coady, Saiss, Semedo, Neves, Podence, Nouri, Neto, Willian Jose, Traore.
Subs: Hoever, Silva, Gibbs-White, Vitinha, Ruddy, Richards, Kilman, Otasowie, Marques.
