With Manuel Pellegrini fighting for his West Ham future, the Chilean is facing calls to make changes at St Mary’s after Monday’s dismal display in the 3-1 defeat by Arsenal.
But Pellegrini has not changed much during this run of one win in 11 matches and it is hard to see the team he selects being too different against Southampton.
Aaron Cresswell is back in training after being forced off against Arsenal and West Ham hope he will be fit to start at left-back.
Michail Antonio is likely to continue to lead the line ahead of the out-of-form Sebastien Haller, while Pellegrini has constantly stayed loyal to Felipe Anderson despite his poor displays this season.
With Lukasz Fabianski still a couple of weeks away from returning from his hip injury, David Martin will keep his place in goal.
Issa Diop could come back in at centre-back after being left on the bench for the last two games since he returned from suspension.

West Ham (4-2-3-1): Martin; Fredericks, Diop, Ogbonna, Cresswell; Rice, Noble; Fornals, Anderson, Snodgrass; Antonio.