West Ham returned to winning ways after beating Newcastle United 2-0 at the London Stadium.
After losing 1-0 to Manchester City earlier in the week, the hosts responded in fashion with a comfortable and largely controlled display in front of their fans.
It took just seven minutes for Manuel Pellegrini’s side to take the lead, with Declan Rice finding the back of the net for his second goal of the season.
Mark Noble doubled the lead from the penalty spot three minutes before the break.
After the restart West Ham continued to dominate proceedings as the visitors struggled to make their presence felt, aside from a late free-kick which struck the woodwork. The result sees the Londoners move up to ninth in the table on 39 points.
Re-live the action below:
Good morning and welcome to The Independent's live coverage of today's 3pm Premier League matches, with both Manchester United and Manchester City in action.
With all eyes on the north London derby at 12:30pm, the two Manchester clubs take a bit of a back seat, but they will have their attentions on the result between Tottenham and Arsenal as it could have a huge impact on the remainder of the season for these two sides. United are just a point off Arsenal and, more interestingly, five points off third-placed Spurs, while City will be hoping for an Arsenal victory to see Tottenham's title challenge killed off for good.
Once the 3pm games get underway, it's off to Old Trafford we go where Ole Gunnar Solskjaer's side are looking to continue their charge up the table as they take on relegation-threatened Southampton. City meanwhile are heading to the south coast to take on Bournemouth, who are looking to get back into the top half of the table.
Elsewhere, Brighton can further dent Huddersfield's hopes as the face off in a relegation battle at the Amex, while Burnley host Crystal Palace at Turf Moor. High-flying Wolves take on Cardiff City, while the day's evening kick-off sees West Ham take on Newcastle at the London Stadium.
Team news for the 3pms will be released an hour before kick-off and we'll bring you all the latest as they drop at 2pm.
In the meantime, here are our predicted line-ups for Manchester United's meeting with Saints:
The teams have arrived at Old Trafford!
Team news due to land in five minutes time...
TEAM NEWS: BOURNEMOUTH VS MANCHESTER CITY
TEAM NEWS: BRIGHTON VS HUDDERSFIELD TOWN
TEAM NEWS: BURNLEY VS CRYSTAL PALACE
TEAM NEWS: MANCHESTER UNITED VS SOUTHAMPTON
TEAM NEWS: WOLVES VS CARDIFF CITY
Afternoon all.
Honours even in the North London derby at Wembley as Arsenal and Tottenham got the footballing weekend started, and we've five more games to bring you live updates from at three o'clock.
South-coast opposition for both Manchester clubs this afternoon with City at the Vitality Stadium and United welcoming Southampton to Old Trafford.
We'll be focusing on how they get on during the course of the 90 minutes and bring you goal updates from elsewhere, so let's get to it. Kick-off is less than half-an-hour away...
Ole Gunnar Solskjaer has a clear target in mind for his team - usurping perhaps his only rival for the long-term managerial post at Old Trafford:
Oleksandr Zinchenko continues at left-back for Pep Guardiola's Manchester City this afternoon, with Benjamin Mendy a continued absentee.
The Spaniard has admitted he is concerned with the Frenchman's injury record.
All smiles on arrival. Manchester United can move back into the top-four with a win.
15 minutes until kick-off in our five 3pm games...
Carabao Cup in the bag, Pep Guardiola is in position early as his team look to return to the top of the table with Liverpool in Merseyside derby action tomorrow.
Ten minutes until kick-off around the grounds.
Final instructions given, handshakes exchanged, Premier League anthem digested.
It's time...
1 minutes
Two five-at-the-back formations for Manchester United and Manchester City to deal with this afternoon, both Southampton and Bournemouth set up to frustrate.
Manchester United 0-0 Southampton, 2 minutes
Top save from Angus Gunn!
The Southampton stopper gets down low to his left and just about gets fingertips to a Romelu Lukaku effort, turning it past the post.
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