West Ham United have a mountain to climb - on paper - before the match has even started as they welcome a Manchester United side looking to continue their strong run against the Hammers.
The Irons are 18/5 with Grosvenor Sport while Man United are the favourites at 10/13 and a draw is 11/4.
The Inside Track's Tom Phillips is backing Cristiano Ronaldo to continue his fine return to Old Trafford with a goal at the London Stadium as the Irons prepare without their main man Michail Antonio up top who is serving a suspension.
However, West Ham have started strongly after completing their strongest campaign in the Premier League since the 1998-99 season.
United will be looking to respond strongly after suffering a shock defeat in the Champions League to Swiss side Young Boys while David Moyes' side had a fantastic start to their Europa League campaign with an away win at Dinamo Zagreb.
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Team stats
West Ham have won two of their last six Premier League games against Man United - with one draw and three defeats - though they are winless in three against the visitors.
Before that, the Irons won just one of their last 19 against United in the competition - losing 13 of them.
United have won their last two Premier League meetings with West Ham and looking for their first three back-to-back wins since September 2014.
Player stats
Said Benrahma will be West Ham's main attacking threat with the former Brentford man picking up two goals and two assists already in the league season.
Cristiano Ronaldo has started strongly too as he begins his second stint at United. The Portuguese forward scored a double on his debut and found the net midweek in the Champions League.
H2H
This will be the 147th meeting between the two sides with United having the better record between the two sides with 69 wins to West Ham's 39 plus 45 draws.
West Ham have only picked up one win in their last six meetings between the two clubs in all competitions.
Form
United have started strongly and find themselves joint-top going into the weekend with a win potentially putting them at the top of the table depending on goal difference and other results going their way.
For West Ham, they are unbeaten in their first four games with two wins and two draws.
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