The Hammers hosts the Foxes in the first Monday Night Football of the new Premier League season.
Both teams are looking to make it two wins out of two and join Chelsea, Liverpool, Tottenham and Brighton with 100 per cent records.
West Ham twice came from behind to beat Newcastle last time out, while Leicester rode their luck at times in a 1-0 win over Wolves.
A win for the Hammers, in front of the first capacity crowd at the London Stadium in 18 months, would lay down a marker against a team who finished one point above them last season and will again be looking to qualify for the Champions League.
Leicester are struggling with injuries, especially in defence, with new signing Jannik Vestergaard the latest to be ruled out after a training ground setback.
