Samir Nasri has failed to shake off his calf injury in time to face Fulham on Friday night.
The midfielder has made just three appearances since he moved to West Ham on a free transfer in December at the end of his 18-month doping ban.
Hammers manager Manuel Pellegrini could name Manuel Lanzini on the bench against Fulham after seven months out with a serious knee injury.
Fabian Balbuena is also back in contention following a knee problem.
The Paraguayan centre-back, a summer signing from Corinthians, has not featured since the 2-0 home defeat by Watford on December 22.
With both teams having been eliminated from the FA Cup before the fifth round, Friday's fixture represents a first for West Ham and Fulham since February 9.
The hosts have climbed to 10th after consecutive 1-1 draws against Liverpool and Crystal Palace, while Claudio Ranieri's struggling side are 19th and eight points adrift of safety after back-to-back defeats.
