Wales' health minister Eluned Morgan has told the Welsh Rugby Union that the Welsh Government will be disappointed if they decide to play home Six Nations matches in England to get around the stricter Covid regulations here.
She has also suggested they would be less inclined to help the Union out financially if they were to head across the Severn Bridge.
The WRU face losing millions if they are forced to play some or all of their three home matches in front of empty stands in Cardiff.
Spectators are currently banned at professional sporting matches in Wales, but capacity crowds are allowed in England as things stand.
Scotland, Ireland, France and Italy all currently have their own varying restrictions.
With the WRU facing a financial blow they simply cannot afford after the catastrophic impact of the pandemic over the past 20 months, the prospect of moving games to England has been mooted, with Tottenham Hotspur's stadium mentioned as one possibility.
It is understood the WRU would be reluctant to do this in reality as they are keen to work with and follow Welsh Government guidance, but nothing can be totally ruled out at this stage.
Wales are scheduled to play Scotland on February 12, followed by France on March 11 and Italy on March 19.
Although it is still too early to be certain of anything, the direction of travel could see a scenario whereby Welsh crowd restrictions are still in place for the first match but are lifted by the time the last two come around.
The health minister told the BBC: "Obviously we all want to see the rugby happening in Wales and we'd be disappointed if the WRU made that decision [to go to England].
"Clearly there would be financial consequences for them and there would be an understanding from the Welsh Government that we would have to step in and support them financially if they did have to postpone those matches or to cancel them in some way.
"Obviously if they did go to England it would be more difficult for us to come up with that financial support.
"We'll see what happens. It's early days. The fact is this variant is moving very quickly. What we're hoping is we'll reach the peak and come down very quickly after that. I believe two of the matches are due to played in March so we'll see if we are out of the woods by then."
It has been reported Six Nations bosses will not postpone any matches this year on the grounds of fans not being allowed.
First Minister Mark Drakeford is due to announce the outcome of the latest Covid review on Friday.
Fans have been banned from attending professional sports events in Wales since Boxing Day, when new rules were introduced in a bid to slow the spread of the Omicron Covid variant.
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