Liverpool defender Virgil van Dijk has pulled out of the Holland squad.
Van Dijk led Holland to a 0-0 draw against Northern Ireland on Saturday night as they qualified for the European Championships.
But the Dutch FA announced on Sunday that Van Dijk would play no part in the final qualifier against Estonia.
Van Dijk has left the squad due to "personal circumstances".
Liverpool return to action after the international break against Crystal Palace as they bid to continue their unbeaten start to the Premier League season.
Last weekend's 3-1 win over Manchester City saw them go nine points clear of the champions.
Liverpool are already sweating on the fitness of Mohamed Salah, Andy Robertson, Joe Gomez and Jordan Henderson after they all left their respective camps.
Jurgen Klopp is already without injured pair Joel Matip and Xherdan Shaqiri.
Van Dijk has played every single minute in the Premier League for Liverpool so far this season.
He admits criticism from boss Jurgen Klopp has made him an even better player.
“I have a very similar connection with Jurgen Klopp at Liverpool as I had earlier with Ronald Koeman at Southampton and I still have with Koeman with the national team," he said.
“Like Koeman, Klopp knows exactly how to get the best out of me – by being critical. When the media are hyping me and being very positive, he will downplay the praise all that – often with a wink.
