In what promises to be a competitive contest, Manchester United face West Ham United in the Carabao Cup on Wednesday evening.
Ole Gunnar Solskjaer will be hoping to progress through to the next stage of the competition, as the wait for his first major piece of silverware as United boss goes on.
It's expected both teams will field slightly weaker XIs, having faced each other three days ago at the London Stadium in a dramatic Premier League encounter.
That was the latest of many exciting contests down the years between the two clubs, who've battled it out and given supporters moments of joy and despair.
We've taken a look at some of the best cup games between the Reds and the Hammers.
1. Manchester United 6-0 West Ham - January 26, 2003
What a performance this was.
Going into the match, West Ham were on a dreadful run in the Premier League and United were already through to the League Cup final.
Ryan Giggs and Ruud van Nistelrooy both struck twice in an embarrassingly one-sided game, with defender Phil Neville and substitute Solskjaer also joining in on the goalscoring fun.
Van Nistelrooy's first was absolutely delightful. He picked up possession in between two defenders on the edge of the area, before dragging the ball with his right and scoring with the outside of his left foot.
It sent United through to the fifth round of the FA Cup and ended up being an embarrassing day for Irons' supporters.
2. West Ham 1-2 Manchester United - April 13, 2016
This was a replay after a 1-1 draw at Old Trafford, which included a quite brilliant free-kick from Dimitri Payet, and proved to be another pulsating contest.
Marcus Rashford gave Louis van Gaal's Reds the lead after 54 minutes with a sensational finish into the top left-hand corner of Darren Randolph's net.
And when Marouane Fellaini bundled in Anthony Martial's cross 13 minutes later it was all but game over, with a semi-final showdown against the Belgian's former employers Everton secured.
United would go on and lift the trophy, beating Crystal Palace 2-1 in the final. But a memorable and triumphant cup run could not save Van Gaal's job.
3. West Ham 2-2 Manchester United - January 5, 2013
Robin van Persie scored in stoppage time as United remained in the FA Cup by a thread and denied West Ham a famous win.
Tom Cleverley gave the Reds the lead when he passed the ball into the net before James Collins headed the equaliser.
Collins gave the Hammers the lead with another header after the break.
With seconds remaining though, Van Persie latched on to Ryan Giggs's sensational ball over the top to earn United a replay at Old Trafford. They would go on to win that game 1-0, courtesy of a goal from Wayne Rooney.
Another brilliant game that even brought one of the final instances of a 'Fergie-time' goal. Very nostalgic!
4. Manchester United 4-1 West Ham - November 30, 2016
It was perhaps one of Jose Mourinho's better moments as Manchester United manager and he wasn't even on the sidelines during this game due to a one-match touchline ban.
Doubles from both Zlatan Ibrahimovic and Anthony Martial sent United into the EFL Cup semi-final. They would go on to win the competition, with a 3-2 victory against Southampton in the final.
United were so comfortable in the game that even Bastian Schweinsteiger managed to make his first appearance for the club in over six months.
Will United beat West Ham in the cup? Follow our United On My Mind writer Omar Garrick on Twitter to get involved in the discussion and give us your thoughts on the matter in the comments section below.
