The Government hopes to have 60% of the population fully vaccinated by June.
Announcing Ireland's new Living with Covid plan on Tuesday, Taoiseach Micheal Martin also confirmed a raft of ambitious jab targets.
He said that we are making "steady progress", claiming that a major ramping up of the programme will take place in the coming weeks.
Although only 350,000 people have received a dose to date, he outlined hopes that 100,000 people per week would be administered a dose in March.
This will be pushed up to 250,000 a week - or one million a month - for April, May and June.
Should those targets be met, 82% of adults will have received their first dose by the end of June, while up to 60% would be fully vaccinated.
In a state of the nation address, he said: "The first of our people being vaccinated are those who are most vulnerable to the disease, and those who we rely on to make our health system work.
"We are making steady progress – over 350,000 vaccine doses have already been administered, but we are now in a position to implement a major ramping up of the programme.
"Ranging from small local GP surgeries and pharmacists, up to a nationwide network of community and regional vaccination centres, we are implementing a programme of vaccination on a scale that is unprecedented in the country’s history.
"By the end of March, we will have administered 1.25million doses.
"Then, depending on vaccines arriving as scheduled, we will administer, on average, more than one million doses per month during April, May and June.
"What that means in practical terms is that by the end of April, up to 47% of people over 18 will have had their first dose.
"By the end of May, up to 64% will have had their first dose.
"And by the end of June, up to 82% of adults who can be vaccinated will have received at least one dose and 55% - 60% will be fully vaccinated."
He later added: "I know that the end is now truly in sight.
"We have already shown what a remarkably resilient people we are. We have drawn on a deep innate sense of community and solidarity to get us this far.
"That’s why, I know, that we will get through this."
