Day Eight at Flushing Meadows begun under the shadow of Novak Djokovic's disqualification from the tournament after he hit a line judge with the ball.
The top seed swatted away a ball in a fit of frustration and hit a lineswoman in the throat. Lengthy discussions ended with the Serbian defaulted and ordered to pay back all prize money he had won thus far.
The top-ranked men's competitor, Dominic Thiem, took full advantage with an impressive dismantling of highly-rated Canadian Felix Auger Aliassime as he bids to win his first Grand Slam. Meanwhile, Danil Medvedev swept aside Francis Tiafoe with ease and the Russian will face compatriot Andrey Rublev in the quarter-finals.
Serena Williams, who continues her quest to match Margaret Court's Grand Slam record of wins, was made to fight hard as she battled past Maria Sakkari in three sets.
There was a shock exit in round four, however, as Sofia Kenin stumbled out in a straight to 16th seed Elise Mertens, who will face Victoria Azarenka in the last eight.
Follow all the action with Standard Sport's LIVE blog.
- Mertens stuns Kenin to set up Azarenka clash
- Marvellous Medvedev crushes Tiafoe
- Thiem strolls past Auger Aliassime
- Serena Williams battles past Sakkari
- Rublev knocks out Berrettini
Order of Play (times in BST)
Arthur Ashe Stadium
17:00: (15) Maria Sakkari (Gre) 3-6, 7-6, 3-6 (3) Serena Williams (USA), (15) Felix Auger-Aliassime (Can) 6-7, 1-6, 1-6 (2) Dominic Thiem (Aut), Frances Tiafoe (USA) 4-6, 1-6, 0-6 (3) Daniil Medvedev (Rus), (16) Elise Mertens (Bel) 6-3, 6-3 (2) Sofia Kenin (USA)
Louis Armstrong Stadium
16:00: Vasek Pospisil (Can) 6-7, 3-6, 2-6 (21) Alex De Minaur (Aus), Alize Cornet (Fra) 4-6, 6-7, 3-6 Tsvetana Pironkova (Bul), (6) Matteo Berrettini (Ita) 6-4, 3-6, 3-6, 3-6 (10) Andrey Rublev (Rus), Victoria Azarenka (Blr) 5-7, 6-1, 6-4 (20) Karolina Muchova (Cze)
Court 17
16:00: (1) Gabriela Dabrowski (Can) 4-6, 2-6 Alison Riske (USA) v Asia Muhammad (USA) & Taylor Townsend (USA), Jamie Murray (Gbr) & Neal Skupski (Gbr) 2-6, 6-7 Mate Pavic (Cro) & Bruno Soares (Bra), Jean-Julien Rojer (Ned) & Horia Tecau (Rom) 7-5, 7-5 Rohan Bopanna (Ind) & Denis Shapovalov (Can), (3) Nicole Melichar (USA) & Yi Fan Xu (Chn) 6-2, 6-3 Hayley Carter (USA) & Luisa Stefani (Bra)
