Coronavirus infections in the US have leapt up by 45,242 in a single day - the largest 24-hour increase of the whole pandemic.
The worrying surge brings the total number of Americans who have tested positive for the deadly bug to more than 2.48 million, according to Reuters.
Several states have rowed back from lifting lockdown measures amid the steep rise.
In Texas, Republican Governor Greg Abbott has ordered bars to close and restaurants to limit indoor seating capacity to 50%.
The state, which had been a trailblazer in lifting restrictions and allowed bars to re-open in May, reported 5,996 new cases on Thursday.
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It has also seen record numbers of hospitalisations in the last two weeks.
The news comes as yet another blow to businesses only just recovering from the brink of ruin due to lockdown measures.
Tish Keller, owner of the Triple J Chophouse and Brew Co. in the city of Lubbock said: "We were just getting to where we could pay the bills.
"Taking us back down to 50% capacity means we won’t have enough business to pay staff, let alone the bills."
Meanwhile in Florida, where the number of cases has shot up by 8,942 in a single day, bars have been stopped from serving alcohol.
The figure eclipses the state's previous one-day record of 5,511, which was reached on June 24.
In California, Governor Gavin Newsom recommended a fresh stay-at-home order in Imperial County after declaring it was "overwhelmed" by the virus.
And in Alaska, Anchorage Mayor Ethan Berkowitz issued an emergency order requiring residents to wear masks in public, indoor spaces after the state identified 836 cases on Friday.
Alabama, Arizona, California, Georgia, Idaho, Mississippi, Missouri, Nevada, Oklahoma, South Carolina, Tennessee and Wyoming also all recorded record rises in cases this week.
It comes as the number of lives lost to Covid-19 in the US reaches nearly 125,000, the highest known death toll from the highly infections disease in the world.
Despite the grim news, Donald Trump said on Friday that the country was recovering from the crisis.
"We have a little work to do, and we’ll get it done," he said at a White House event.
"We’re having some very good numbers coming out in terms of the comeback, the comeback of our nation, and I think it’s going very rapidly and it’s going to be very good."
Vice President Mike Pence has said that many of the new infections in Texas and Florida are among young people with no symptoms.
"We’re seeing more and more young people, under the age of 35, who are testing positive," he said.
"In many cases they have no symptoms."
