Edinson Cavani lost his fitness battle and was not healthy enough to start Uruguay's World Cup quarter-final with France.
The PSG star was Uruguay's two-goal hero against Portugal in the last-16, but could not recover in time from his calf injury to start the game in Nizhny Novgorod.
There was a degree of mystery with the Albiceleste's teamsheet indicating the 31-year-old was on the bench but official Fifa documentation confirmed he was indeed injured and out of the game.
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Former Middlesbrough striker Cristhian Stuani lined up alongside Barcelona star Luis Suarez in attack for the South Americans instead in an otherwise unchanged side.
Meanwhile, Les Bleus coach Didier Deschamps was also forced into a change as well.
Corentin Tolisso came in for the suspended Blaise Matuidi in midfield in the only alteration to the side that beat Argentina 4-3 in a thriller in the last round.
The European side's attack is spearheaded once again by Olivier Giroud with Kylian Mbappe, hero of the win over Argentina on Saturday, and Antoine Griezmann alongside him.
