Ryan Giggs' side, however, will be keen to replicate their opening 4-1 win against their rivals, though they'll be without Gareth Bale this time round in light of a mystery injury that is keeping him out of the squad.
Elsewhere, France host Germany in Paris in the stand-out fixture for tonight's international football. Joachim Low is under increasing pressure following Germany football's group stage exit at the World Cup and winless start to the new competition.
More of the same from Ireland and Wales. Both sides have impressed with their defensive organisation thus far and neither side has a creative player or a real influencer to break them down.
James McClean won't be heading to Denmark next month - he's picked up a booking for a trip on Harry Wilson and is thus suspended for Ireland's next Nations League game.
A deflected Lucas Hernandez shot forces a corner, and Blaise Matuidi's effort is blocked behind again.
France can't force an opening, but a slightly better opening to the second half from the hosts. Looks to be a little more drive in the team since the resumption.
Half-time in Dublin. It hasn't been vintage. Both Wales and the Republic of Ireland have struggled to find their attacking rhythm, with the vast majority of the game being played in the middle of the pitch. 0-0
Half-time at the Stade de France in Paris. Germany have been the better team and hold a deserved 1-0 lead over the World Cup winners thanks to Toni Kroos' penalty.
Better from the home side in Paris - Antoine Griezmann clips a lovely ball over the top and the sliding Kylian Mbappe can't quite get a toe on the ball to beat Manuel Neuer. France's best moment thus far.
Matthias Ginter rises mightily to meet Toni Kroos' out swinger and could perhaps do better, heading over-the-top with little opposition a couple of yards beyond the six yard box.
More of the same in Dublin. Both teams are relatively comfortable moving the ball in defence and midfield but are unable to find the incision required to breakdown either defence.
It is poor and Griezmann is forced to perform some defensive duties as Germany counter at pace.
Germany's three forward-most players (Werner, Sane, Gnabry) are very quick and they are worrying the France defence again before Griezmann flicks Leroy Sane's cross to safety.
Sky Sports will be showing live coverage of Ireland vs Wales on Sky Sports Main Event and Sky Sports Football with coverage beginning from 7:00pm. S4C will also be showing coverage from 7:25pm.
France vs Germany will be shown live on Sky Sports Mix from 7:40pm.
Both matches can be steamed online via SkyGo for Sky customers or on Now TV.
Odds
Republic of Ireland to win: 7/5
Wales to win: 5/2
Draw: 9/5
France to win: 1/1
Germany to win: 14/5
Draw: 13/5
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