Two men have been charged after police dismantled a large-scale clandestine drug lab and seized 10 kilograms of methylamphetamine as well as cash on the NSW Central Coast.

Strike Force Garlow detectives tried to stop a black Toyota Kluger at Ourimbah on Tuesday afternoon.

Police say the Kluger rammed two police cars, injuring a senior constable, before two men emerged from the Toyota and ran off.

Police dogs helped track the men - aged 35 and 48 - who were arrested and taken to Wyong Police Station.

Police later searched an Ourimbah home, seizing drug paraphernalia, $220,000 in cash, an electronic stun device and a ballistic vest.

A later search at a rural property in Kulnura uncovered more than 10kg of methylamphetamine, a large quantity of methylamphetamine oil, more than 20kg of precursor chemicals used in the manufacture of prohibited drugs as well as equipment consistent with the large-scale manufacture of prohibited drugs.

Both men were charged with manufacturing a commercial quantity of a prohibited drug and supplying a commercial quantity of a prohibited drug.

The 35-year-old man was also charged with knowingly dealing with the proceeds of crime, while the 48-year-old man was charged with using an offensive weapon in company to prevent detention.

Both were refused bail and appeared at Wyong Local Court on Wednesday where they were formally refused bail to reappear at the same court on November 2.