TUI has cancelled all holidays to Florida for UK and Ireland up to the end of November due to the coronavirus pandemic.
Families hoping to visit the famous theme parks this summer were told that their holidays had been scrapped as TUI said new measures in place had halted travel.
The UK's biggest tour operator said in a statement that the news was down to the new policies in place at Disney World.
The firm said in a statement: "The decision has been made following new health and safety measures implemented at Walt Disney World to ensure the safety of its guests.
"These changes would significantly impact the holiday experience for many Tui customers who plan their magical and often once in a lifetime Florida holiday."
Anyone with holidays booked can reschedule it up until October 2021, or secure a full refund.
But Brits could be banned from travelling to the US for months under strict restrictions, which have been in place since March 16.
America’s top public health official, Dr Anthony Fauci previously said the travel ban would likely be lifted in months rather than weeks.
He told the Telegraph: "It's going to be really wait and see. I don't think there's going to be an immediate pull back for those kinds of restrictions.
"My feeling, looking at what's going on with the infection rate, I think it's more likely measured in months rather than weeks."
An air bridge - which would allow UK travellers to skip mandatory quarantine rules - is unlikely as the US coronavirus figures continue to rise.
Paul Charles from pressure group Quash Quarantine, told Sun Online Travel: "It is unlikely that America will open up before the November election, partly because President Trump won’t open it up, but also because the number of cases there is very high."
TUI also previously extended the suspension of all beach holidays for UK customers until July 10.
It had previously planned to restart travel on July 1.
At the time, a spokeswoman said: “We are constantly monitoring the situation and will start taking people on holiday again as soon as we are able to do so.”
But holidaymakers will only be able to travel to places where they will not need to quarantine.
This could see travel allowed to countries such as Greece, France, Spain and Turkey, as they are expected to be amongst the first countries that the UK announces 'air bridges' with.
In an email to customers, the travel firm said: "This means we won’t travel to places where we know that you’ll need to self-isolate when you arrive or when you return home."
The Foreign Office currently advises against all but essential travel but this is expected to change imminently.
The Prime Minister is set to give the green light to foreign holidays to holiday hotspots today, sources have claimed.
All major UK tour operators will not run trips until the government changes its position.
